我司经销商长春新产业公司(CNI)光遗传学和神经学用激光器

光遗传学是一个蓬勃发展的多学科生物工程技术，结合了重组DNA技术与光学技术，对细胞生物学的研究非常有用，具有独特的高时空分辨率和细胞类型特异性的特点，克服了传统手段控制细胞或有机体活动的许多缺点。光遗传学被广泛应用于活细胞内目标蛋白质的跟踪以及选择性地控制脑中某类细胞的特定的神经活动从而推动了神经科学研究的深入。近来光遗传学的应用拓展到了信号传导的研究，也开始有医学临床的应用的报道。

神经学是神经系统的科学研究，是一门跨学科的科学，与其他领域如化学、计算机科学、工程学、语言学、数学、医学、遗传学、哲学、物理学和心理学均有关联。一些基于光学方法的研究技术已成为神经科学领域的主要研究手段。神经科学的研究范围非常广泛，包括神经系统的功能、节后、发育、遗传和病理学等方面，而其中对功能、结构及功能与结构关联的研究更是核心内容。在对神经系统结构的研究中，不断进步的光学成像技术一直发挥着重要作用。

长春新产业公司(CNI)是依托中科院长春光机所设立的企业，主要从事激光器的研发与生产。公司先后通过了ISO9001认证、欧洲CE、RoHS认证、美国FDA认证、日本JQA认证。公司现可提供光基因遗传用激光光源（自由空间或光纤耦合），光纤、植入式光纤插针、可旋转光纤连接器、机械快门、声光调制器、激光防护镜等相关配件，以及整套测试系统。

◆ 特 征
    CNI可提供自主研发生产的高可靠性激光光源；
    可提供光基因遗传与神经学用测试系统的所有必须组件；
    易于安装、拆卸及维护；
    可提供客户定制的解决方案。

 ◆光遗传学常用激光器
紫外波段（nm）:    266   351   355   360   375
蓝光波段(nm):    405   435   442   445   447   457   460   465   473   488   491
绿光波段 (nm):    515   520   532   543   556   561
黄光波段 (nm):    589   593
红光波段 (nm):    633   637   640   642   650   671   690   720   750
红外波段 (nm):    785   800   808   825   830   905   915   940   980  1064   1342  1990   2200
多波长激光器 (nm):    蓝/ 绿/ 黄/ 红

完整配件：

 

◆使用CNI激光器取得的光遗传学相关研究成果

 (1) Optogenetic stimulation of a hippocampal engram activates fear memory recall
      (Nature, 484(7394): 381–385. doi:10.1038/nature11028) (CNI-473nm)

 (2) Ultrahigh accuracy imaging modality for super-localization microscopy
      (Nature Methods, VOL.10,2013,335) (CNI-635nm and 488nm)

 (3) Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task
      (ORIGINALRESEARCH doi: 10.3389/fnbeh.2015.00286) (CNI-589nm)

 (4) Optogenetic Evidence That Pallidal Projections, Not Nigral Projections, from the Nucleus Accumbens Core Are Necessary
       for Reinstating Cocaine Seeking (The Journal of Neuroscience, 2013•33(34):13654–13662) (CNI-561nm)

 (5) Control of a specific motor program by a small brain area in zebrafish
      (Front Neural Circuits, 2013; 7: 67) (CNI-405nm and 457nm)

 (6) Fatal Neurological Respiratory Insufficiency Is Common Among Viral Encephalitides (Oxford Journals, 2013:208) (CNI-470nm)

 (7) Temperature-dependent Activation of Neurons by Continuous Near-infrared Laser
      (Cell Biochemistry and Biophysics,vol.53, 33-42,2009)(CNI-1064nm)

 (8) Distal connectivity causes summation and division across mouse visual cortex (Nature Neuroscience, 2014,Volume:17,Pages:

      30–32) (CNI-473nm)

 (9) Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers
      (PNAS,2012,109(22),8483-8488) (CNI-980nm)

 (10) Viral Vector-Based Techniques for Optogenetic Modulation In Vivo
       (Viral Vector Approaches in Neurobiology and Brain Diseases Neuromethods, Volume 82, 2014, pp 289-310) (CNI-447nm)

 (11) Optogenetic Inhibition of Dorsal Medial Prefrontal Cortex Attenuates Stress-Induced Reinstatement of Palatable Food Seeking in
        Female Rats (The Journal of Neuroscience, 2013, 33(1):214–226) (CNI-593.5nm)

 (12) Glutamatergic Signaling by Mesolimbic Dopamine Neurons in the Nucleus Accumbens
        (The Journal of Neuroscience, 2010, 30(20):7105-7110) (CNI-453nm)

 (13) Firing of Hippocampal Neurogliaform Cells Induces Suppression of Synaptic Inhibition
        (The Journal of Neuroscience, 2014•34(4):1280–1292) (CNI-532nm)

 (14) Intrinsic Electrophysiology of Mouse Corticospinal Neurons: a Class-Specific Triad of Spike-Related Properties
        (Oxford Journals, Volume 23,Issue 8,1965-1977) (CNI-473nm)

 (15) Au–PLA nanocomposites for photothermally controlled drug delivery (J. Mater. Chem. B, 2014,2, 409-417)(CNI-808nm)

 (16) Synthesis of magnetic, fluorescent and mesoporous core-shell-structured nanoparticles for imaging, targeting and photodynamic
        therapy (J. Mater. Chem., 2011,21, 11244-11252)(CNI-660nm)

 (17) Asphaltene Adsorption onto an Iron Surface: Combined Near-Infrared (NIR), Raman, and AFM Study of the Kinetics,
        Thermodynamics and Layer Structure (Energy Fuels,2011,25(1), pp 189–196)(CNI-633nm)

 (18) The electrophysiological properties of voltage-gated potassium channels on cultivated porcine retinal ganglion cells irradiated with
        continuous near-infrared laser (Chinese journal of ophthalmology 02/2012; 48(2):153-8).(CNI-845nm)

 (19) High-resolution simultaneous voltage and Ca2+imaging (J Physiol February 1, 2011.589(3)489-494)(CNI-543nm)